P. Khodarahmi; H. Nasrollahzade Phili; M. Heydari Nasrabadi
Volume 3, Issue 4 , July 2015, , Pages 79-87
Abstract
Abstract
Silver nanoparticles have numerous applications in food technology and medical industry. These applications are mediated via their mitotic, oxidative and apoptotic effects. In this study, the apoptotic effects of short and long term administrations of nanosilver on rat hippocampus, which is ...
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Abstract
Silver nanoparticles have numerous applications in food technology and medical industry. These applications are mediated via their mitotic, oxidative and apoptotic effects. In this study, the apoptotic effects of short and long term administrations of nanosilver on rat hippocampus, which is involved in memory and learning, was investigated. 56 male Wistar rats were divided into two groups of short term and long term injections which were treated for 5 and 10 consecutive days, respectively. Each group was divided into four subgroups of control, 100, 200 and 400 ppm nanosilver administration. The control subgroup received saline and the treatment subgroups received intraperitoneal injections of silver nanoparticles at doses of 100, 200 and 400ppm. Ten days after the last injection, the hippocampal tissue sections were prepared and the extent of apoptosis was evaluated using TUNEL assay. In short term (5-day injection) group, the percentage of apoptotic cells between control and 100 (p
